Weighing Molecules with Light-a new way to study biomolecules
Matthias Langhorst, Refeyn Ltd
Wednesday, June 19, 2019
2:00pm–3:00pm
12-0168, MIT.nano (basement level), Building 12
60 Vassar Street (rear)
Cambridge, MA
In this talk, Dr. Matthias Langhorst will discuss the principles behind mass photometry, a technology based on interferometric scattering microscopy. It represents a truly novel approach capable of analysing individual biomolecules in solution by measuring their mass. Given that most physiological and pathological processes rely on the interaction between different biomolecules, an approach that cannot only observe these species in a universal, label-free fashion, but also measure their mass accurately and with the molecular resolution, could be transformative for our ability to characterise the composition, structure and dynamics of biomolecules. Applications include accurate determination of the degree of heterogeneity of biomolecule samples, quantification of molecular interaction strengths and kinetics, optimizing conditions for sample stability and interactions, studies of self-assembly processes as well as precise characterisation of molecular concentration. Dr. Langhorst will illustrate the unique capabilities of mass photometry by discussing a broad selection of recent examples and provide insight into the strengths and limitations of the approach.
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